Miller was injured on his first carry of the game but Guiton came in and tossed an option pitch to Wilson for a touchdown on his first play behind center.
From there, it was a blowout. Guiton led the Buckeyes with 83 yards rushing on nine carries while throwing for 152 yards on 19 of 28 passing. Corey Brown caught a pair of touchdown passes while Devin Smith had a team-high seven catches for 46 yards.
C.J. Barnett led the Buckeyes with seven tackles in his return to the starting lineup after missing the season opener because of injury.
Stay tuned to BuckeyeSports.com for more coverage throughout the evening.