OSU (7-1) was making its first appearance since last Thursday's home loss to No. 3 LSU.
Jessica Davenport led four Buckeyes to score in double figures with 19 points to help Ohio State win for the 21st time in their last 22 home games.
Ohio State held Sacred Heart scoreless for the first 4:35 of the game and seven Buckeyes scored in the first 10 minutes of action en route to a 29-10 lead at the 9:34 mark. In the opening 10 minutes, Ohio State, which led the country in field goal percentage each of the last two seasons, connected on 14 of its first 17 shot attempts from the field.
By the end of the half, 10 Buckeyes tallied at least one field goal as Ohio State extended its lead to 47-21 at the break. Davenport led the Buckeyes in the first period with 10 points as Ohio State scored 32 of its 47 first-half points in the paint and connected on 59 percent (22-37) of its field goal attempts. The Buckeyes also turned 15 SHU turnovers in 22 points.
Ohio State continued to score at-will from the inside in the second half, opening a 67-34 lead on a Davenport put-back with 9:27 to play. Marscilla Packer followed shortly with a three-point shot to give Ohio State an insurmountable 70-34 lead with just less than eight minutes to go.
Debbie Merrill followed Davenport with a season-high 14 points, while Brandie Hoskins added 12 and Kim Wilburn contributed 10. Wilburn also finished with four steals to become just the second Buckeye all-time to record 300 career steals.
Davenport also pulled down eight rebounds.
Nicole Rubino led Sacred Heart (6-2) with 13 points.
The Buckeyes return to action at 7 p.m. Thursday against Cansius in VCA.